[Photo/VCG] BEIJING -- Chinese scientists have found a new therapeutic target for rejuvenating aging cells, shedding light on possible gene therapy for osteoarthritis. Osteoarthritis is characterized by the degeneration of articular cartilage, which seriously affects the quality of life of the elderly. Aging and mesenchymal stem cell attrition are considered the main causes of osteoarthritis. Therefore, revealing the molecular mechanisms of mesenchymal stem cell aging will provide clues for effective intervention for osteoarthritis. Scientists from the Institute of Biophysics of the Chinese Academy of Sciences (CAS), Peking University and the Institute of Zoology of the CAS have found that a protein named CBX4 safeguards mesenchymal stem cells against cellular aging, thus controlling the development of osteoarthritis. Experiments on mice show that the overexpression of CBX4 alleviates cellular senescence, inhibits inflammation and stimulates cartilage regeneration, thereby effectively controlling the pathological process of osteoarthritis. According to Liu Guanghui, one of the corresponding authors, the finding not only highlights CBX4 as a key gatekeeper for mesenchymal stem cell aging but also open possibilities for treating age-related disorders in the future. The research proves the feasibility of using gene therapy strategies to rejuvenate senescent cells and treat osteoarthritis, providing a promising option for future geriatrics and regenerative medicine, Liu said. The research was published in the journal Cell Reports. breast cancer awareness wristbandsevent wristbands ukpalestine silicone wristbandcustom silicone wristbandsid wristband child
SINGAPORE - Singapore's Ministry of Foreign Affairs confirmed on late Thursday that the meeting between Donald Trump, president of the United States, and Kim Jong-un, top leader of the Democratic People's Republic of Korea (DPRK), is to be held in the city-state.Singapore is pleased to host the meeting between the two leaders on June 12, said the ministry in a statement, adding, "we hope this meeting will advance prospects for peace in the Korean Peninsula."Trump tweeted earlier on Thursday that the highly anticipated meeting between Kim Jong-un and himself will take place in Singapore on June 12, and said," We will both try to make it a very special moment for World Peace!" personalized awareness braceletsbuy wristbands near mepretty little liars bracelet customwhite rubber bracelet meaningnumbered silicone wristbands<%2fcenter>
